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KMID : 0043320090320040521
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Archives of Pharmacal Research
2009 Volume.32 No. 4 p.521 ~ p.526
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A Fluorenone Alkaloid from Caulophyllum robustum Maxim. with Anti-myocardial Ischemia Activity
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He Lang-Chong
Liu Jun-Tian
Wang Na
Wen Bin-Yu
Wang Si-Cen
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Abstract
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A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustumMaxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.
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KEYWORD
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Caulophyllum robustum Maxim., Caulophine, Anti-myocardial ischemia
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